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A multinomial model for the quality control of colony counting procedures

Author

Listed:
  • Voss, B.
  • Dahms, S.
  • Kunert, Joachim
  • Weiss, H.

Abstract

The so-called good-laboratory-practice (GLP) test provides an experimental design and appropriate statistical analysis for the problem of analyst performance assessment in microbiological laboratories. For a given sample material multiple dilution series are generated yielding colony counts from several dilution levels. Statistical evaluation is based on the assumption of Poisson-distributed colony forming units. In this paper a new model based on conditional binomial and multinomial distributions is presented and it is shown how it is related to the standard model which assumes Poisson-distributed colony counts. The effects of common working errors on the statistical evaluation of the GLP-test are investigated.

Suggested Citation

  • Voss, B. & Dahms, S. & Kunert, Joachim & Weiss, H., 1999. "A multinomial model for the quality control of colony counting procedures," Technical Reports 1999,19, Technische Universität Dortmund, Sonderforschungsbereich 475: Komplexitätsreduktion in multivariaten Datenstrukturen.
    • Handle: RePEc:zbw:sfb475:199919
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