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Skin microcirculatory reactivity assessed using a thermal challenge is decreased in patients with circulatory shock and associated with outcome

Author

Listed:
  • Diego Orbegozo Cortes
  • Wasineenart Mongkolpun
  • Gianni Stringari
  • Nikolaos Markou
  • Jacques Creteur
  • Jean Louis Vincent
  • Daniel De Backer

Abstract

Background: Shock states are characterized by impaired tissue perfusion and microcirculatory alterations, which are directly related to outcome. Skin perfusion can be noninvasively evaluated using skin laser Doppler (SLD), which, when coupled with a local thermal challenge, may provide a measure of microcirculatory reactivity. We hypothesized that this microvascular reactivity would be impaired in patients with circulatory shock and would be a marker of severity. Methods: We first evaluated skin blood flow (SBF) using SLD on the forearm and on the palm in 18 healthy volunteers to select the site with maximal response. Measurements were taken at 37 °C (baseline) and repeated at 43 °C. The 43 °C/37 °C SBF ratio was calculated as a measure of microvascular reactivity. We then evaluated the SBF in 29 patients with circulatory shock admitted to a 35-bed department of intensive care and in a confirmatory cohort of 35 patients with circulatory shock. Results: In the volunteers, baseline SBF was higher in the hand than in the forearm, but the SBF ratio was lower (11.2 [9.4–13.4] vs. 2.0 [1.7–2.6], p

Suggested Citation

  • Diego Orbegozo Cortes & Wasineenart Mongkolpun & Gianni Stringari & Nikolaos Markou & Jacques Creteur & Jean Louis Vincent & Daniel De Backer, 2018. "Skin microcirculatory reactivity assessed using a thermal challenge is decreased in patients with circulatory shock and associated with outcome," ULB Institutional Repository 2013/278245, ULB -- Universite Libre de Bruxelles.
    • Handle: RePEc:ulb:ulbeco:2013/278245
    Note: SCOPUS: ar.j
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