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The unsuspected "bodyguards" of red blood cells

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  • Zangari del Balzo, Gianluigi

Abstract

Transferrin is the main intrabody carrier of iron. An in-depth analysis of the struc- ture, conformation distribution and functions of this protein allowed us to predict its unsuspected “non-canonical” function in the metabolism of mature red blood cells. In this work we propose a theory of the energy landscape with static and dynamic macro- molecular simulations, performed with an unconventional statistical calculus, which analyze the conformation transformations of Transferrin from a closed to an open and activated structure (“open jaws”) during the follow-up of mature red blood cells. The result is a finite set of N states of low entropy, of which a subset N-p corresponds to conformations of minimum entropy where Transferrin binds to a specialized receptor, surviving in mature red blood cells.

Suggested Citation

  • Zangari del Balzo, Gianluigi, 2020. "The unsuspected "bodyguards" of red blood cells," OSF Preprints k2ubf, Center for Open Science.
    • Handle: RePEc:osf:osfxxx:k2ubf
    DOI: 10.31219/osf.io/k2ubf
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