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Adverse Outcome Pathway on Alkylation of DNA in Male Pre-Meiotic Germ Cells Leading to Heritable Mutations

Author

Listed:
  • Carole Yauk

    (Environmental Health Science and Research Bureau, Health Canada)

  • Iain Lambert

    (Carleton University)

  • Francesco Marchetti

    (Environmental Health Science and Research Bureau, Health Canada)

  • George Douglas

    (Environmental Health Science and Research Bureau, Health Canada)

Abstract

Germ cell/heritable mutations are important regulatory endpoints for international agencies interested in protecting the health of future generations. However, germ cell mutation analysis has been hampered by a lack of efficient tools. The motivation for developing this AOP was to provide context for new assays in this field, identify research gaps and facilitate the development of new methods. In this AOP, a compound capable of alkylating DNA is delivered to the testes causing germ cell mutations and subsequent mutations in the offspring of the exposed parents. Although there are some gaps surrounding some mechanistic aspects of this AOP, the overarching AOP is widely accepted and applies broadly to any species that produces sperm.

Suggested Citation

  • Carole Yauk & Iain Lambert & Francesco Marchetti & George Douglas, 2016. "Adverse Outcome Pathway on Alkylation of DNA in Male Pre-Meiotic Germ Cells Leading to Heritable Mutations," OECD Series on Adverse Outcome Pathways 3, OECD Publishing.
    • Handle: RePEc:oec:envaad:3-en
    DOI: 10.1787/5jlsvvxn1zjc-en
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    Keywords

    DNA adducts; DNA alkylation; DNA repair; heritable mutations; male pre-meiotic germ cells;
    All these keywords.

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