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Constructing a utility algorithm for the pressure ulcer quality of life-utility instrument (PUQOL-UI)

Author

Listed:
  • Carolyn Czoski-Murray

    (Leeds Institute of Health Sciences, University of Leeds)

  • David Meads

    (Leeds Institute of Health Sciences, University of Leeds)

  • Richard Edlin

    (School of Population Health, University of Auckland, New Zealand)

  • Claire Hulme

    (Leeds Institute of Health Sciences, University of Leeds)

  • Claudi Gorecki

    (Clinical Trials Research Unit, University of Leeds)

  • Jane Nixon

    (Clinical Trials Research Unit, University of Leeds)

  • Christopher McCabe

    (University of Alberta, Edmonton, Canada)

Abstract

Aim: Pressure Ulcers are an important health care problem, recognized as ‘Never Events’ by the US Government. To date, there is no instrument to capture their health utility impact, or the value of treatments and prevention strategies. The Pressure Ulcer Quality of Life Utility Instrument (PUQol-UI) is a condition specific preference-based measure designed to capture the impact of having a pressure ulcer (PU) on an individual’s health related quality of life and will allow calculation of QALYs necessary for cost-effectiveness analyses. PUQol-UI consists of 7 domains (Pain, Mobility, Activities of Daily Living, Energy, Depression, Burden and Social Function). Each domain has three possible response levels: ‘No Bother’, ‘Little Bother’, and ‘A lot of Bother’. Methods: A valuation exercise obtained Time Trade-Off values for 51 PUQol-UI health states in 200 interviews with the UK General Population. OLS, Random Effects and Fixed Effects linear regression models were fitted and evaluated using tests of standard goodness of fit and estimation and validation sample predictive performance. Results: The Random Effects model was superior in fit and predictive performance, with 83% of states predicted to within 0.1 of the observed mean. Preliminary analysis of the psychometric properties of the PUQoL-UI indicates adequate levels of validity and may offer measurement advantages over the generic EQ-5D measure. Conclusions: The PUQol-UI is a useful addition to the portfolio of condition specific utility measures available to researchers interested in economic evaluation of technologies for the management of pressure ulcers, and health care decision makers responsible for funding such technologies.

Suggested Citation

  • Carolyn Czoski-Murray & David Meads & Richard Edlin & Claire Hulme & Claudi Gorecki & Jane Nixon & Christopher McCabe, 2014. "Constructing a utility algorithm for the pressure ulcer quality of life-utility instrument (PUQOL-UI)," Working Papers 1404, Academic Unit of Health Economics, Leeds Institute of Health Sciences, University of Leeds.
    • Handle: RePEc:lee:wpaper:1404
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    File URL: http://medhealth.leeds.ac.uk/download/938/auhe_wp14_04
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    Keywords

    Cost-effective Analysis; QALYs; PUQoL; Pressure Ulcer; Quality of life;
    All these keywords.

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