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Testosterone is positively associated with coronary artery calcium in a low cardiovascular disease risk population

Author

Listed:
  • Benjamin C. Trumble

    (Unknown)

  • Jacob Negrey

    (Unknown)

  • Stephanie Koebele

    (Unknown)

  • Randall C. Thompson

    (Unknown)

  • L. Samuel Wann

    (Unknown)

  • Adel H. Allam

    (Unknown)

  • Bret A. Beheim

    (Unknown)

  • Linda Sutherland

    (Unknown)

  • James Sutherland

    (Unknown)

  • Daniel Eid Rodriguez

    (Unknown)

  • David E. Michalik

    (Unknown)

  • Christophe J. Rowan

    (Unknown)

  • Guido Lombardi

    (Unknown)

  • Angela Garcia

    (Unknown)

  • Daniel Cummings

    (Unknown)

  • Edmond Seabright

    (Unknown)

  • Sarah Alami

    (Unknown)

  • Thomas S. Kraft

    (Unknown)

  • Paul L. Hooper

    (Unknown)

  • Kenneth Buetow

    (Unknown)

  • Andrei Irimia

    (Unknown)

  • Margaret Gatz

    (Unknown)

  • Jonathan Stieglitz

    (IAST - Institute for Advanced Study in Toulouse)

  • Michael Gurven

    (Unknown)

  • Hillard Kaplan

    (Unknown)

  • Gregory Thomas

    (Unknown)

Abstract

In industrialized populations low male testosterone is associated with higher rates of cardiovascular mortality. However, coronary risk factors like obesity impact both testosterone and cardiovascular outcomes. Here we assess the role of endogenous testosterone on coronary artery calcium in an active subsistence population with relatively low testosterone levels, low cardiovascular risk, and low coronary artery calcium scores. In this cross-sectional community-based study, 719 Tsimane forager-horticulturalists in the Bolivian Amazon aged 40+ years underwent computed tomography (49.8% male, mean age 57.6 years). Coronary artery calcium levels were low; 84.5% had no coronary artery calcium. Zero inflated negative binomial models found testosterone was positively associated with coronary artery calcium for the full sample (IRR= 1.477, 95% CI 1.001-2.170, p=0.031), and in a male-only subset (IRR=1.532, 95% CI 0.993-2.360, p=0.053). Testosterone was also positively associated with clinically relevant coronary atherosclerosis (calcium >100 Agatston units) in the full sample (OR = 1.984, 95% CI 1.202-3.275, p=0.007) and when limited to male only sample (OR= 2.032, 95% CI 1.118-4.816, p=0.024). Individuals with coronary artery calcium >100 had 20% higher levels of testosterone than those with calcium

Suggested Citation

  • Benjamin C. Trumble & Jacob Negrey & Stephanie Koebele & Randall C. Thompson & L. Samuel Wann & Adel H. Allam & Bret A. Beheim & Linda Sutherland & James Sutherland & Daniel Eid Rodriguez & David E. M, 2023. "Testosterone is positively associated with coronary artery calcium in a low cardiovascular disease risk population," Post-Print hal-04547874, HAL.
    • Handle: RePEc:hal:journl:hal-04547874
    DOI: 10.1093/emph/eoad039
    as

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