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Prevalence of dementia and mild cognitive impairment in indigenous Bolivian forager-horticulturalists

Author

Listed:
  • Margaret Gatz

    (Unknown)

  • Wendy Mack

    (Unknown)

  • Helena Chui

    (Unknown)

  • Meng Law

    (Unknown)

  • Giuseppe Barisano

    (Unknown)

  • Linda Sutherland

    (Unknown)

  • James Sutherland

    (Unknown)

  • Jonathan Stieglitz

Abstract

We evaluated the prevalence of dementia and mild cognitive impairment (MCI) in indigenous Tsimane and Moseten, who lead a subsistence lifestyle. Methods : Participants from population-based samples ≥ 60 years of age (n = 623) were assessed using adapted versions of the Modified Mini-Mental State Examination, informant interview, longitudinal cognitive testing and brain computed tomography (CT) scans. Results : Tsimane exhibited five cases of dementia (among n = 435; crude prevalence = 1.2%, 95% confidence interval [CI]: 0.4, 2.7); Moseten exhibited one case (among n = 169; crude prevalence = 0.6%, 95% CI: 0.0, 3.2), all age ≥ 80 years. Age-standardized MCI prevalence was 7.7% (95% CI: 5.2, 10.3) in Tsimane and 9.8% (95% CI: 4.9, 14.6) in Moseten. Cognitive impairment was associated with visuospatial impairments, parkinsonian symptoms, and vascular calcification in the basal ganglia. Discussion : The prevalence of dementia in this cohort is among the lowest in the world. Widespread intracranial medial arterial calcifications suggest a previously unrecognized, non-Alzheimer's disease (AD) dementia phenotype.

Suggested Citation

  • Margaret Gatz & Wendy Mack & Helena Chui & Meng Law & Giuseppe Barisano & Linda Sutherland & James Sutherland & Jonathan Stieglitz, 2023. "Prevalence of dementia and mild cognitive impairment in indigenous Bolivian forager-horticulturalists," Post-Print hal-04067662, HAL.
    • Handle: RePEc:hal:journl:hal-04067662
    DOI: 10.1002/alz.12626
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