IDEAS home Printed from https://ideas.repec.org/p/hal/journl/hal-01482357.html
   My bibliography  Save this paper

Impact of quadrivalent influenza vaccine on public health and ă influenza-related costs in Australia

Author

Listed:
  • Aurelien Jamotte
  • Chui Fung Chong
  • Andrew Manton
  • Berengere Macabeo
  • Mondher Toumi

    (Pharmaco-Epidémiologie - Université Bordeaux Segalen - Bordeaux 2 - INSERM - Institut National de la Santé et de la Recherche Médicale)

Abstract

Background: Annual trivalent influenza vaccines (TIV) containing three ă influenza strains (A/H1N1, A/H3N2, and one B) have been recommended for ă the prevention of influenza. However, worldwide co-circulation of two ă distinct B lineages (Victoria and Yamagata) and difficulties in ă predicting which lineage will predominate each season have led to the ă development of quadrivalent influenza vaccines (QIV), which include both ă B lineages. Our analysis evaluates the public health benefit and ă associated influenza-related costs avoided which would have been ă obtained by using QIV rather than TIV in Australia over the period ă 2002-2012. ă Methods: A static model stratified by age group was used, focusing on ă people at increased risk of influenza as defined by the Australian ă vaccination recommendations. B-lineage cross-protection was accounted ă for. We calculated the potential impact of QIV compared with TIV over ă the seasons 2002-2012 (2009 pandemic year excluded) using Australian ă data on influenza circulation, vaccine coverage, hospitalisation and ă mortality rates as well as unit costs, and international data on vaccine ă effectiveness, influenza attack rate, GP consultation rate and working ă days lost. Third-party payer and societal influenza-related costs were ă estimated in 2014 Australian dollars. Sensitivity analyses were ă conducted. ă Results: Using QIV instead of TIV over the period 2002-2012 would have ă prevented an estimated 68,271 additional influenza cases, 47,537 GP ă consultations, 3,522 hospitalisations and 683 deaths in the population ă at risk of influenza. These results translate into influenza-related ă societal costs avoided of \46.5 million. The estimated impact of QIV ă was higher for young children and the elderly. The overall impact of QIV ă depended mainly on vaccine effectiveness and the influenza attack rate ă attributable to the mismatched B lineage. ă Conclusion: The broader protection offered by QIV would have reduced the ă number of influenza infections and its related complications, leading to ă substantial influenza-related costs avoided.

Suggested Citation

  • Aurelien Jamotte & Chui Fung Chong & Andrew Manton & Berengere Macabeo & Mondher Toumi, 2016. "Impact of quadrivalent influenza vaccine on public health and ă influenza-related costs in Australia," Post-Print hal-01482357, HAL.
    • Handle: RePEc:hal:journl:hal-01482357
    DOI: 10.1186/s12889-016-3297-1
    as

    Download full text from publisher

    To our knowledge, this item is not available for download. To find whether it is available, there are three options:
    1. Check below whether another version of this item is available online.
    2. Check on the provider's web page whether it is in fact available.
    3. Perform a search for a similarly titled item that would be available.

    Citations

    Citations are extracted by the CitEc Project, subscribe to its RSS feed for this item.
    as


    Cited by:

    1. Klas Kellerborg & Werner Brouwer & Pieter Baal, 2020. "Costs and benefits of interventions aimed at major infectious disease threats: lessons from the literature," The European Journal of Health Economics, Springer;Deutsche Gesellschaft für Gesundheitsökonomie (DGGÖ), vol. 21(9), pages 1329-1350, December.

    More about this item

    Keywords

    quality;

    Statistics

    Access and download statistics

    Corrections

    All material on this site has been provided by the respective publishers and authors. You can help correct errors and omissions. When requesting a correction, please mention this item's handle: RePEc:hal:journl:hal-01482357. See general information about how to correct material in RePEc.

    If you have authored this item and are not yet registered with RePEc, we encourage you to do it here. This allows to link your profile to this item. It also allows you to accept potential citations to this item that we are uncertain about.

    We have no bibliographic references for this item. You can help adding them by using this form .

    If you know of missing items citing this one, you can help us creating those links by adding the relevant references in the same way as above, for each refering item. If you are a registered author of this item, you may also want to check the "citations" tab in your RePEc Author Service profile, as there may be some citations waiting for confirmation.

    For technical questions regarding this item, or to correct its authors, title, abstract, bibliographic or download information, contact: CCSD (email available below). General contact details of provider: https://hal.archives-ouvertes.fr/ .

    Please note that corrections may take a couple of weeks to filter through the various RePEc services.

    IDEAS is a RePEc service. RePEc uses bibliographic data supplied by the respective publishers.