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Reassessing diabetes and APOE genotype as potential interacting risk factors for Alzheimer’s disease

Author

Listed:
  • Ravipati, Kaushik
  • Chen, Yunxiao
  • Manns, Joseph R.

Abstract

Objective: To assess whether diabetes alone or in association with Apolipoprotein E (APOE) ε4 genotype increases the risk of Alzheimer’s Disease (AD) diagnosis. Methods: A retrospective cohort study of 33,456 participants from the National Alzheimer’s Coordinating Center database. Results: Participants with one or two APOE ε4 alleles had 2.71 (CI:2.55–2.88) and 9.37 (CI:8.14–10.78) times higher odds of AD diagnosis, respectively, relative to those with zero ε4 alleles. In contrast, diabetic participants showed 1.07 (CI:0.96–1.18) times higher odds of AD relative to nondiabetics. Diabetes did not exacerbate the odds of AD in APOE ε4 carriers. APOE ε4 carriage was correlated with declines in long-term memory and verbal fluency, which were strongly correlated with conversion to AD. However, diabetes was correlated with working memory decline, which had a relatively weak correlation with AD. Conclusions: Unlike APOE ε4, there was little evidence that diabetes was a risk factor for AD.

Suggested Citation

  • Ravipati, Kaushik & Chen, Yunxiao & Manns, Joseph R., 2022. "Reassessing diabetes and APOE genotype as potential interacting risk factors for Alzheimer’s disease," LSE Research Online Documents on Economics 113607, London School of Economics and Political Science, LSE Library.
    • Handle: RePEc:ehl:lserod:113607
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    File URL: http://eprints.lse.ac.uk/113607/
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    More about this item

    Keywords

    Alzheimer’s Disease; APOE ε4 allele; diabetes; long-term memory; structural equation modeling; working memory;
    All these keywords.

    JEL classification:

    • C1 - Mathematical and Quantitative Methods - - Econometric and Statistical Methods and Methodology: General

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