IDEAS home Printed from https://ideas.repec.org/p/cdl/ctcres/qt64b2w0k2.html
   My bibliography  Save this paper

Second hand smoke stimulates tumor angiogenesis and growth

Author

Listed:
  • Zhu, B Q
  • Heeschen, C
  • Sievers, R E
  • Karliner, J S
  • Parmley, W W
  • Glantz, Stanton A. Ph.D.
  • Cooke, J P

Abstract

Exposure to second hand smoke (SHS) is believed to cause lung cancer. Pathological angiogenesis is a requisite for tumor growth. Lewis lung cancer cells were injected subcutaneously into mice, which were then exposed to sidestream smoke (SHS) or clean room air and administered vehicle, cerivastatin, or mecamylamine. SHS significantly increased tumor size, weight, capillary density, VEGF and MCP-1 levels, and circulating endothelial progenitor cells (EPC). Cerivastatin (an inhibitor of HMG-coA reductase) or mecamylamine (an inhibitor of nicotinic acetylcholine receptors) suppressed the effect of SHS to increase tumor size and capillary density. Cerivastatin reduced MCP-1 levels, whereas mecamylamine reduced VEGF levels and EPC. These studies reveal that SHS promotes tumor angiogenesis and growth. These effects of SHS are associated with increases in plasma VEGF and MCP-1 levels, and EPC, mediated in part by isoprenylation and nicotinic acetylcholine receptors.

Suggested Citation

  • Zhu, B Q & Heeschen, C & Sievers, R E & Karliner, J S & Parmley, W W & Glantz, Stanton A. Ph.D. & Cooke, J P, 2003. "Second hand smoke stimulates tumor angiogenesis and growth," University of California at San Francisco, Center for Tobacco Control Research and Education qt64b2w0k2, Center for Tobacco Control Research and Education, UC San Francisco.
    • Handle: RePEc:cdl:ctcres:qt64b2w0k2
    as

    Download full text from publisher

    File URL: https://www.escholarship.org/uc/item/64b2w0k2.pdf;origin=repeccitec
    Download Restriction: no
    ---><---

    Citations

    Citations are extracted by the CitEc Project, subscribe to its RSS feed for this item.
    as


    Cited by:

    1. Regina Grazuleviciene & Asta Danileviciute & Ruta Nadisauskiene & Jone Vencloviene, 2009. "Maternal Smoking,GSTM1 and GSTT1 Polymorphism and Susceptibility to Adverse Pregnancy Outcomes," IJERPH, MDPI, vol. 6(3), pages 1-16, March.

    More about this item

    Statistics

    Access and download statistics

    Corrections

    All material on this site has been provided by the respective publishers and authors. You can help correct errors and omissions. When requesting a correction, please mention this item's handle: RePEc:cdl:ctcres:qt64b2w0k2. See general information about how to correct material in RePEc.

    If you have authored this item and are not yet registered with RePEc, we encourage you to do it here. This allows to link your profile to this item. It also allows you to accept potential citations to this item that we are uncertain about.

    We have no bibliographic references for this item. You can help adding them by using this form .

    If you know of missing items citing this one, you can help us creating those links by adding the relevant references in the same way as above, for each refering item. If you are a registered author of this item, you may also want to check the "citations" tab in your RePEc Author Service profile, as there may be some citations waiting for confirmation.

    For technical questions regarding this item, or to correct its authors, title, abstract, bibliographic or download information, contact: Lisa Schiff (email available below). General contact details of provider: https://escholarship.org/uc/ctcre/ .

    Please note that corrections may take a couple of weeks to filter through the various RePEc services.

    IDEAS is a RePEc service. RePEc uses bibliographic data supplied by the respective publishers.