IDEAS home Printed from https://ideas.repec.org/p/bep/uwabio/1044.html
   My bibliography  Save this paper

Adjusting for Non-Ignorable Verification Bias in Clinical Studies for Alzheimer's Disease

Author

Listed:
  • Xiao-Hua Zhou

    (University of Washington)

  • Pete Castelluccio

    (Purdue University)

Abstract

A common problem for comparing the relative accuracy of two screening tests for Alzheimer's disease (D) in a two-stage design study is verification bias. If the verification bias can be assumed to be ignorable, Zhou and Higgs (2000) have proposed a maximum likelihood approach to compare the relative accuracy of screening tests in a two-stage design study. However, if the verification mechanism also depends on the unobserved disease status, the ignorable assumption does not hold. In this paper, we discuss how to use a profile likelihood approach to compare the relative accuracy of two screening tests for AD without assuming the ignorable verification bias mechanism.

Suggested Citation

  • Xiao-Hua Zhou & Pete Castelluccio, 2004. "Adjusting for Non-Ignorable Verification Bias in Clinical Studies for Alzheimer's Disease," UW Biostatistics Working Paper Series 1044, Berkeley Electronic Press.
    • Handle: RePEc:bep:uwabio:1044
    Note: oai:bepress.com:uwbiostat-1044
    as

    Download full text from publisher

    File URL: http://www.bepress.com/cgi/viewcontent.cgi?article=1044&context=uwbiostat
    Download Restriction: no
    ---><---

    Citations

    Citations are extracted by the CitEc Project, subscribe to its RSS feed for this item.
    as


    Cited by:

    1. Frederico Z. Poleto & Julio M. Singer & Carlos Daniel Paulino, 2011. "Comparing diagnostic tests with missing data," Journal of Applied Statistics, Taylor & Francis Journals, vol. 38(6), pages 1207-1222, April.
    2. Khanh To Duc & Monica Chiogna & Gianfranco Adimari, 2019. "Estimation of the volume under the ROC surface in presence of nonignorable verification bias," Statistical Methods & Applications, Springer;Società Italiana di Statistica, vol. 28(4), pages 695-722, December.

    Corrections

    All material on this site has been provided by the respective publishers and authors. You can help correct errors and omissions. When requesting a correction, please mention this item's handle: RePEc:bep:uwabio:1044. See general information about how to correct material in RePEc.

    If you have authored this item and are not yet registered with RePEc, we encourage you to do it here. This allows to link your profile to this item. It also allows you to accept potential citations to this item that we are uncertain about.

    We have no bibliographic references for this item. You can help adding them by using this form .

    If you know of missing items citing this one, you can help us creating those links by adding the relevant references in the same way as above, for each refering item. If you are a registered author of this item, you may also want to check the "citations" tab in your RePEc Author Service profile, as there may be some citations waiting for confirmation.

    For technical questions regarding this item, or to correct its authors, title, abstract, bibliographic or download information, contact: Christopher F. Baum (email available below). General contact details of provider: http://www.bepress.com .

    Please note that corrections may take a couple of weeks to filter through the various RePEc services.

    IDEAS is a RePEc service. RePEc uses bibliographic data supplied by the respective publishers.