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How does ClinicalTrials.gov Impact Company Innovation?

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  • Yazhou Niu

Abstract

Pharmaceutical companies may have incentives to exaggerate the therapeutic effects of their developed products during the clinical stage, which endangers the health of patients. To increase transparency in clinical practice, the NIH established ClinicalTrials.gov in 2000, which indicates a significant impact on medicine. However, little evidence shows how ClinicalTrials.gov affects medical enterprises innovation. By identifying the patent application activities through USPTO, Pubmed, and Compustat, we used coherent DID to prove the impact of ClinicalTrials.gov on innovation. We found that the emergence of ClinicalTrials.gov reduced the number of patent applications and led to a shift in RD directions. This effect can also be moderated depending on firm size, probably because small companies are more incentivized to manipulate data. Hence, we suggest agencies could consider wide-ranging influences when formulating open science policies.

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  • Yazhou Niu, 2024. "How does ClinicalTrials.gov Impact Company Innovation?," Papers 2405.07998, arXiv.org.
    • Handle: RePEc:arx:papers:2405.07998
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    References listed on IDEAS

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    1. Asba Tasneem & Laura Aberle & Hari Ananth & Swati Chakraborty & Karen Chiswell & Brian J McCourt & Ricardo Pietrobon, 2012. "The Database for Aggregate Analysis of ClinicalTrials.gov (AACT) and Subsequent Regrouping by Clinical Specialty," PLOS ONE, Public Library of Science, vol. 7(3), pages 1-12, March.
    2. Seru, Amit, 2014. "Firm boundaries matter: Evidence from conglomerates and R&D activity," Journal of Financial Economics, Elsevier, vol. 111(2), pages 381-405.
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