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Indication Sequencing for a New Molecular Entity with Multiple Potential Oncology Indications

In: Optimization of Pharmaceutical R&D Programs and Portfolios

Author

Listed:
  • Jack Kloeber

    (Kromite LLC)

  • Alex Stojanovic

    (Phosphagenics)

  • C. Kwon Kim

    (Kromite LLC)

Abstract

In this chapter, we address portfolio optimization at a sub-portfolio level. Even a “mini” portfolio—such as a single molecule with numerous indication opportunities—can pose a significant challenge to an organization; there are many interdependencies, correlations, and synergies to consider, weigh, and trade off. Here we present a case study that considers the challenge of optimizing this sub-portfolio by determining the best sequence of three potential indications. The same methods can be applied to a molecule with even more indication opportunities, a group of related molecules, or an entire portfolio.

Suggested Citation

  • Jack Kloeber & Alex Stojanovic & C. Kwon Kim, 2015. "Indication Sequencing for a New Molecular Entity with Multiple Potential Oncology Indications," Springer Books, in: Zoran Antonijevic (ed.), Optimization of Pharmaceutical R&D Programs and Portfolios, edition 127, chapter 0, pages 123-139, Springer.
    • Handle: RePEc:spr:sprchp:978-3-319-09075-7_8
    DOI: 10.1007/978-3-319-09075-7_8
    as

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