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Dynamic Modeling and Control of a Continuous Biopharmaceutical Manufacturing Plant

In: Optimization of Pharmaceutical Processes

Author

Listed:
  • Mohammad Amin Boojari

    (Tarbiat Modares University)

  • Simone Perra

    (Technical University of Denmark)

  • Giorgio Colombo

    (Technical University of Denmark)

  • Matteo Grossi

    (Technical University of Denmark)

  • Mark Nicholas Jones

    (Technical University of Denmark)

  • Isuru Udugama

    (Technical University of Denmark)

  • Morteza Nikkhah Nasab

    (AmirKabir University of Technology (Tehran Polytechnic))

  • Mohammad Fakroleslam

    (Tarbiat Modares University)

  • Ali M. Sahlodin

    (AmirKabir University of Technology (Tehran Polytechnic))

  • Seyed Abbas Shojaosadati

    (Tarbiat Modares University)

  • Krist V. Gernaey

    (Technical University of Denmark)

  • Seyed Soheil Mansouri

    (Technical University of Denmark)

Abstract

The application of model-based tools in biopharmaceutical industry is an active area of research to design, control and analysis of existing and future production of new drugs and therapeutics. In this chapter, a reference plant-wide model for production of a biopharmaceutical compound is proposed. It captures the generic process dynamics of a biopharmaceutical process. As such, it is well-suited to use as a test problem to evaluate different processing scenarios in continuous and semi-continuous fermentation processes.

Suggested Citation

  • Mohammad Amin Boojari & Simone Perra & Giorgio Colombo & Matteo Grossi & Mark Nicholas Jones & Isuru Udugama & Morteza Nikkhah Nasab & Mohammad Fakroleslam & Ali M. Sahlodin & Seyed Abbas Shojaosadati, 2022. "Dynamic Modeling and Control of a Continuous Biopharmaceutical Manufacturing Plant," Springer Optimization and Its Applications, in: Antonios Fytopoulos & Rohit Ramachandran & Panos M. Pardalos (ed.), Optimization of Pharmaceutical Processes, pages 323-353, Springer.
    • Handle: RePEc:spr:spochp:978-3-030-90924-6_12
    DOI: 10.1007/978-3-030-90924-6_12
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