IDEAS home Printed from https://ideas.repec.org/h/spr/oprchp/978-3-319-89920-6_50.html
   My bibliography  Save this book chapter

Preventing Hot Spots in High Dose-Rate Brachytherapy

In: Operations Research Proceedings 2017

Author

Listed:
  • Björn Morén

    (Linköping University
    Linköping University)

  • Torbjörn Larsson

    (Linköping University)

  • Åsa Carlsson Tedgren

    (Karolinska University Hospital
    Karolinska Institute)

Abstract

High dose-rate brachytherapy is a method of radiation cancer treatment, where the radiation source is placed inside the body. The recommended way to evaluate dose plans is based on dosimetric indices which are aggregate measures of the received dose. Insufficient spatial distribution of the dose may however result in hot spots, which are contiguous volumes in the tumour that receive a dose that is much too high. We use mathematical optimization to adjust a dose plan that is acceptable with respect to dosimetric indices to also take spatial distribution of the dose into account. This results in large-scale nonlinear mixed-binary models that are solved using nonlinear approximations. We show that there are substantial degrees of freedom in the dose planning even though the levels of dosimetric indices are maintained, and that it is possible to improve a dose plan with respect to its spatial properties.

Suggested Citation

  • Björn Morén & Torbjörn Larsson & Åsa Carlsson Tedgren, 2018. "Preventing Hot Spots in High Dose-Rate Brachytherapy," Operations Research Proceedings, in: Natalia Kliewer & Jan Fabian Ehmke & Ralf Borndörfer (ed.), Operations Research Proceedings 2017, pages 369-375, Springer.
    • Handle: RePEc:spr:oprchp:978-3-319-89920-6_50
    DOI: 10.1007/978-3-319-89920-6_50
    as

    Download full text from publisher

    To our knowledge, this item is not available for download. To find whether it is available, there are three options:
    1. Check below whether another version of this item is available online.
    2. Check on the provider's web page whether it is in fact available.
    3. Perform a search for a similarly titled item that would be available.

    Corrections

    All material on this site has been provided by the respective publishers and authors. You can help correct errors and omissions. When requesting a correction, please mention this item's handle: RePEc:spr:oprchp:978-3-319-89920-6_50. See general information about how to correct material in RePEc.

    If you have authored this item and are not yet registered with RePEc, we encourage you to do it here. This allows to link your profile to this item. It also allows you to accept potential citations to this item that we are uncertain about.

    We have no bibliographic references for this item. You can help adding them by using this form .

    If you know of missing items citing this one, you can help us creating those links by adding the relevant references in the same way as above, for each refering item. If you are a registered author of this item, you may also want to check the "citations" tab in your RePEc Author Service profile, as there may be some citations waiting for confirmation.

    For technical questions regarding this item, or to correct its authors, title, abstract, bibliographic or download information, contact: Sonal Shukla or Springer Nature Abstracting and Indexing (email available below). General contact details of provider: http://www.springer.com .

    Please note that corrections may take a couple of weeks to filter through the various RePEc services.

    IDEAS is a RePEc service. RePEc uses bibliographic data supplied by the respective publishers.