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Crosstalk between SARS-CoV-2 and Testicular Hemostasis: Perspective View

In: Biotechnology to Combat COVID-19

Author

Listed:
  • R.G. Ahmed

Abstract

The infection of SARS-CoV-2 and its COVID disease caused several economic and social disturbances worldwide. This chapter aimed to determine the severity of SARS-CoV-2 infection on the testicular hemostasis. This overview showed the possible mechanisms of how the SARS-CoV-2 can infect the testes. SARS-CoV-2-induced pneumonia, cytokine storm, and immunosuppressive state may transfer from the respiratory tract to the blood circulation, binding to testicular angiotensin-converting enzyme 2 receptors (ACSE2) and initiate its intracellular replication and action (cytotoxicity), that disrupting the testicular hemostasis. In severe states, COVID-19 disease can increase body/testes temperature, which may destroy the germ cell in the long term. The final mechanism is that SARS-CoV-2 infection causes stress, panic, and anxiety states, causing brain disorders that may perturb the hypothalamic-pituitary-testes-axis (HPTA). This disturbance may then lead to testicular dysfunction. The severity of COVID-19 may be age-dependent and depending on the expression and distribution of testicular ACSE2 receptors. Also, this chapter not only showed the sexual transmission of SARS-CoV-2 but also followed its impact on sexual behavior, pregnancy, and progeny. Thus, maintaining the testicular hemostasis may play a vital role in a healthy life for the offspring. Further research and clinical studies are required to explore this issue.

Suggested Citation

  • R.G. Ahmed, 2022. "Crosstalk between SARS-CoV-2 and Testicular Hemostasis: Perspective View," Chapters, in: Megha Agrawal & Shyamasri Biswas (ed.), Biotechnology to Combat COVID-19, IntechOpen.
    • Handle: RePEc:ito:pchaps:237914
    DOI: 10.5772/intechopen.98218
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    File URL: https://www.intechopen.com/chapters/77350
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    More about this item

    Keywords

    SARS-CoV-2 (COVID-19); Testes; angiotensin-converting enzyme 2 receptor (ACSE2) HPTA; Pregnancy;
    All these keywords.

    JEL classification:

    • I18 - Health, Education, and Welfare - - Health - - - Government Policy; Regulation; Public Health

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