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The Utility of Mechanical Homogenization in COVID-19 Diagnostic Workflows

In: Biotechnology to Combat COVID-19

Author

Listed:
  • Zachary P. P Morehouse
  • Rodney J. Nash
  • Caleb Proctor
  • Gabriella Ryan

Abstract

The use of mechanical homogenization in patient sample preparation for COVID-19 diagnostics has proven impactful in the face of the global pandemic caused by SARS-CoV-2. Through methods including bead beating and shaker mill homogenization novel approaches to viral detection have been developed and improvements have been made to existing diagnostic workflows for the improvement of throughput and automation capacity. The application of mechanical homogenization techniques has enhanced the sensitivity and methodology for many molecular based approaches to COVID-19 detection and from a variety of sample types ranging from saliva to nasopharyngeal swabs. Additionally, this technology has been used to help increase laboratory safety during sample processing through efficient viral lysis. Herein, the many benefits of mechanical homogenization for COVID-19 detection will be discussed in the context of the many diagnostic workflows currently utilizing the technique.

Suggested Citation

  • Zachary P. P Morehouse & Rodney J. Nash & Caleb Proctor & Gabriella Ryan, 2022. "The Utility of Mechanical Homogenization in COVID-19 Diagnostic Workflows," Chapters, in: Megha Agrawal & Shyamasri Biswas (ed.), Biotechnology to Combat COVID-19, IntechOpen.
    • Handle: RePEc:ito:pchaps:231725
    DOI: 10.5772/intechopen.97110
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    File URL: https://www.intechopen.com/chapters/76026
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    More about this item

    Keywords

    PCR; viral diagnostics; viral detection; antigen diagnostics; antigen detection; molecular diagnostics; COVID-19; homogenization; sample preparation; bead mill; shaker mill; bead beater;
    All these keywords.

    JEL classification:

    • I18 - Health, Education, and Welfare - - Health - - - Government Policy; Regulation; Public Health

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