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Mesenchymal Stem Cells and Extracellular Vesicles: An Emerging Alternative to Combat COVID-19

In: Biotechnology to Combat COVID-19

Author

Listed:
  • Hugo . C. Rodriguez
  • Manu Gupta
  • Emilio Cavazos-Escobar
  • Enrique Montalvo
  • Saadiq F. El-Amin III
  • Ashim Gupta

Abstract

The global SARS-CoV-2 outbreak has been accompanied with severe socio-economic and health burdens that will ripple through history. It is now known that SARS-CoV-2 induces a cytokine storm that leads to acute respiratory distress syndrome and systemic organ damage. With no definitive nor safe therapy for COVID-19 as well as the rise of viral variants the need for an urgent treatment modality is paramount. Mesenchymal stem cells (MSCs) and their extracellular vesicles (EVs) have long been praised for their anti-viral, anti-inflammatory and tissue regenerative capabilities. MSCs and their EVs are now being studied for their possible use as a treatment modality for COVID-19. In this review we explore their capabilities and outline the evidence of their use in ALI, ARDS and COVID-19.

Suggested Citation

  • Hugo . C. Rodriguez & Manu Gupta & Emilio Cavazos-Escobar & Enrique Montalvo & Saadiq F. El-Amin III & Ashim Gupta, 2022. "Mesenchymal Stem Cells and Extracellular Vesicles: An Emerging Alternative to Combat COVID-19," Chapters, in: Megha Agrawal & Shyamasri Biswas (ed.), Biotechnology to Combat COVID-19, IntechOpen.
    • Handle: RePEc:ito:pchaps:231584
    DOI: 10.5772/intechopen.97212
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    More about this item

    Keywords

    COVID-19; Coronavirus; SARS-CoV-2; Mesenchymal stem cells; Extracellular vesicles; Exosomes; Regenerative medicine;
    All these keywords.

    JEL classification:

    • I18 - Health, Education, and Welfare - - Health - - - Government Policy; Regulation; Public Health

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