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Eco-Friendly, Green Approach for Synthesis of Bio-Active Novel 3-Aminoindazole Derivatives

In: Green Computing Technologies and Computing Industry in 2021

Author

Listed:
  • Chandrashekhar Gorakhnath Devkate
  • Satish Shamrao Kola
  • Mohammad Idrees
  • Naqui Siddiqui
  • Roshan Nasare

Abstract

In present chapter we have reported green and highly efficient method for synthesize novel series of substituted -1H-indazol-3-amine derivative (3a-h) by cyclocondensation reaction of substituted benzonitrile (1a-h) and substituted Hydrazine (2a-h) using ceric (IV) ammonium nitrate (CAN) as a catalyst, EtOH-H2O as a ecofriendly media and reaction was carried out under ultrasound irradiation green method. The structures of newly synthesized indazole derivative (3a-h) were corroborated through spectral investigation such as elemental analysis and spectral studies like IR, C13 NMR, Mass spectra and 1H NMR. The compounds were assessed for their in-vitro antimicrobial activity with pathogenic microbe comprising Gram positive bacterial strains, S. aureus and Gram negative strains E.coli, P.vulgaris, and S. typhi at different concentration. The consequence of bioassay is compared with standard drug Chloramphenicol.

Suggested Citation

  • Chandrashekhar Gorakhnath Devkate & Satish Shamrao Kola & Mohammad Idrees & Naqui Siddiqui & Roshan Nasare, 2021. "Eco-Friendly, Green Approach for Synthesis of Bio-Active Novel 3-Aminoindazole Derivatives," Chapters, in: Albert Sabban (ed.), Green Computing Technologies and Computing Industry in 2021, IntechOpen.
    • Handle: RePEc:ito:pchaps:220735
    DOI: 10.5772/intechopen.95565
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    Keywords

    indazol; ceric (IV) ammonium nitrate catalyst; ultrasound irradiation; ecofriendly media; antimicrobial screening;
    All these keywords.

    JEL classification:

    • Q55 - Agricultural and Natural Resource Economics; Environmental and Ecological Economics - - Environmental Economics - - - Environmental Economics: Technological Innovation

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