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Immunological Risks Caused by Fibrous and Particulate Substances

In: Environmental Health Risk - Hazardous Factors to Living Species

Author

Listed:
  • Takemi Otsuki
  • Hiroaki Hayashi
  • Kei Yoshitome
  • Tamayo Hatayama
  • Shoko Yamamoto
  • Naoko Kumagai-Takei
  • Suni Lee
  • Hidenori Matsuzaki
  • Megumi Maeda
  • Yasumitsu Nishimura

Abstract

The immunological risks caused by fibrous and particulate substances, especially the effects caused by asbestos fibers and silica particles, are discussed in this chapter. Patients with silicosis often suffer from autoimmune diseases, such as rheumatoid arthritis, systemic sclerosis, and antineutrophil cytoplasmic antibody-related vasculitis. Silica particles, SiO2, may influence directly various immune cells resulting in the production of many autoantibodies and imbalance between responder and regulatory T cells. The core chemical content of asbestos fibers is Si and O, although the physical feature is different. Considering the complications in asbestos-exposed patients, malignant tumors, such as lung cancer and malignant mesothelioma, are the most important. To think about these situations, asbestos fibers may cause the reduction of antitumor immunity. The experimental findings and measurements of various immunological parameters in silicosis patients, as well as asbestos-exposed population, such as patients with pleural plaque and mesothelioma, are demonstrated and discussed in this chapter.

Suggested Citation

  • Takemi Otsuki & Hiroaki Hayashi & Kei Yoshitome & Tamayo Hatayama & Shoko Yamamoto & Naoko Kumagai-Takei & Suni Lee & Hidenori Matsuzaki & Megumi Maeda & Yasumitsu Nishimura, 2016. "Immunological Risks Caused by Fibrous and Particulate Substances," Chapters, in: Marcelo L. Larramendy & Sonia Soloneski (ed.), Environmental Health Risk - Hazardous Factors to Living Species, IntechOpen.
    • Handle: RePEc:ito:pchaps:101575
    DOI: 10.5772/62749
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    More about this item

    Keywords

    asbestos; silica; autoimmune diseases; antitumor immunity; regulatory T cell;
    All these keywords.

    JEL classification:

    • G32 - Financial Economics - - Corporate Finance and Governance - - - Financing Policy; Financial Risk and Risk Management; Capital and Ownership Structure; Value of Firms; Goodwill

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