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A Stochastic Mechanism For Dna Melting

Author

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  • SENCER TANERI

    (Gazi Muhtar Paşa Cad. Dr. Müfid Ekdal Çık, Manolya Apt. No:1-A-7 Feneryolu, Kadıköy, 34724 Istanbul, Turkey)

Abstract

Deoxyribonucleic acid (DNA) is a kind of nucleic acid consisting of two strands which are made up of two Watson–Crick base pairs: adenine–thymine (AT) and guanine–cytosine (GC). There are three components of the total energy. These are the inharmonic stacking interaction, hydrogen bond interaction and the kinetic energy. Morse potential is used to mimic the hydrogen bond interaction between bases on the opposite strands for the overlapping π electrons, when two neighboring bases move out of the stack. The AT pair has 2 hydrogen bonds and the GC pair has 3 of them. The π electrons obey Bose–Einstein (BE) statistics, and the overlapping of them results in quantum fluctuation. It will be shown that this can be simplified into〈Δy(t)Δy(t)〉 = 2DqΔttype fluctuation between the base pairs. Thus, a metropolis algorithm can be developed for the total potential energy by superposing two potential energy terms as well as including the quantum fluctuation in terms of random displacement of the π electrons. So, one can calculate the melting temperature of base pairs.

Suggested Citation

  • Sencer Taneri, 2013. "A Stochastic Mechanism For Dna Melting," International Journal of Modern Physics C (IJMPC), World Scientific Publishing Co. Pte. Ltd., vol. 24(11), pages 1-11.
    • Handle: RePEc:wsi:ijmpcx:v:24:y:2013:i:11:n:s0129183113500770
    DOI: 10.1142/S0129183113500770
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