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Transport Efficiency Of Passive Diffusion Of Viral Cargos In Biological Cells

Author

Listed:
  • MARISSA G. PASTOR

    (National Institute of Physics, College of Science, University of the Philippines, Diliman, Quezon City 1101, Philippines)

  • JOHNROB Y. BANTANG

    (National Institute of Physics, College of Science, University of the Philippines, Diliman, Quezon City 1101, Philippines)

Abstract

Usingin silicoexperiments, we isolate the effects of geometry on the efficiency of passive diffusion transport,PS, of viral cargos to the nuclear region. We model the cell as an elliptical 2D structure (eccentricitye) containing a circular nucleus with radiiR(semi-minor) andr, respectively. The cargos move in isotropic random walk inside the cell.PSis estimated as the ratio of the number of cargos that reach the nuclear region and of cargos released. We show thatPSdecreases with the total distance traveled but increases withr/R. Shifting the nuclear position inside circular cells(e = 0)produce probability distribution functions of total distance traveled that shifts to shorter modes as one side becomes closer to the cell membrane. On the contrary, cargos in more elongated cells(e = 0)have preservedPS-values even for longer distances of travel inside the cell. Finally, an optimumr/Rexists due to a trade-off between increased efficiency of transport to the nucleus and high cytoplasmic area. This work could contribute in elucidating the reason why some viruses induce asymmetry in their host cells.

Suggested Citation

  • Marissa G. Pastor & Johnrob Y. Bantang, 2011. "Transport Efficiency Of Passive Diffusion Of Viral Cargos In Biological Cells," International Journal of Modern Physics C (IJMPC), World Scientific Publishing Co. Pte. Ltd., vol. 22(04), pages 347-357.
    • Handle: RePEc:wsi:ijmpcx:v:22:y:2011:i:04:n:s0129183111016294
    DOI: 10.1142/S0129183111016294
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