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Polarity-Driven Geometrical Cluster Growth Model Of Budding Yeast

Author

Listed:
  • RENIEL B. CABRAL

    (National Institute of Physics, University of the Philippines, Diliman, 1101 Quezon City, Philippines)

  • MAY T. LIM

    (National Institute of Physics, University of the Philippines, Diliman, 1101 Quezon City, Philippines)

Abstract

We present a polarity-driven activator-inhibitor model of budding yeast in a two-dimensional medium wherein impeding metabolites secretion (or growth inhibitors) and growth directionality are determined by the local nutrient level. We found that colony size and morphological features varied with nutrient concentration. A branched-type morphology is associated with high impeding metabolite concentration together with a high fraction of distal budding, while opposite conditions (low impeding metabolite concentration, high fraction of proximal budding) promote Eden-type patterns. Increasing the anisotropy factor (or polarity) produced other spatial patterns akin to the electrical breakdown under varying electric field. Rapid changes in the colony morphology, which we conjecture to be equivalent to a transition from an inactive quiescent state to an active budding state, appeared when nutrients were limited.

Suggested Citation

  • Reniel B. Cabral & May T. Lim, 2010. "Polarity-Driven Geometrical Cluster Growth Model Of Budding Yeast," International Journal of Modern Physics C (IJMPC), World Scientific Publishing Co. Pte. Ltd., vol. 21(09), pages 1169-1182.
    • Handle: RePEc:wsi:ijmpcx:v:21:y:2010:i:09:n:s0129183110015749
    DOI: 10.1142/S0129183110015749
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