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Positive Feedback-Assisted Short/Long-Range Cell Signalings In Mapk Cascades

Author

Listed:
  • YANBIN ZHANG

    (College of Computer Science, Hangzhou Dianzi University, Hangzhou 310018, China)

  • KENIAN CHEN

    (Department of Biotechnology, Guangzhou Medical College, Guangzhou 510180, China)

  • JUNWEI WANG

    (School of Informatics, Guangdong University of Foreign Studies, Guangzhou 510006, China)

  • AIMIN CHEN

    (School of Mathematics and Computational Science, Sun Yat-Sen University, Guangzhou 510275, China)

  • TIANSHOU ZHOU

    (School of Mathematics and Computational Science, Sun Yat-Sen University, Guangzhou 510275, China;
    School of Life Science, Sun Yat-Sen University, Guangzhou 510275, China)

Abstract

In this paper, we study potentials of positive feedback in spatial phosphoprotein signal propagation. For this, we consider a signaling pathway of four-tiered protein kinase cascades with each tier involving single (de)phosphorylation reactions only. In the case of a small cell, we propose a short positive feedback for short-range cell signaling, which can generate bistability to facilitate the phosphoprotein signal propagation from the plasma membrane to the periphery of cell nucleus. In contrast, in the case of a large cell for which the long-range signaling cannot be achieved by the short feedback, we propose a long positive feedback, and find that it can facilitate the propagation of phosphoprotein signal over a long distance. These results imply that positive-feedback mechanisms would be employed by living organisms for spatial information transfer and cellular decision-making processing.

Suggested Citation

  • Yanbin Zhang & Kenian Chen & Junwei Wang & Aimin Chen & Tianshou Zhou, 2009. "Positive Feedback-Assisted Short/Long-Range Cell Signalings In Mapk Cascades," International Journal of Modern Physics C (IJMPC), World Scientific Publishing Co. Pte. Ltd., vol. 20(11), pages 1769-1787.
    • Handle: RePEc:wsi:ijmpcx:v:20:y:2009:i:11:n:s0129183109014722
    DOI: 10.1142/S0129183109014722
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