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Evidence Of Scale-Free Topology In Gene Regulatory Network Of Human Tissues

Author

Listed:
  • M. ANDRECUT

    (Institute for Biocomplexity and Informatics, University of Calgary, 2500 University Drive NW, Calgary, Alberta, T2N 1N4, Canada)

  • S. A. KAUFFMAN

    (Institute for Biocomplexity and Informatics, University of Calgary, 2500 University Drive NW, Calgary, Alberta, T2N 1N4, Canada)

  • A. M. MADNI

    (Intelligent Systems Technology Inc., 3250 Ocean Park Blvd., Ste. 100, Santa Monica, CA 90405, USA)

Abstract

We report the reconstruction of the topology of gene regulatory network in human tissues. The results show that the connectivity of the regulatory gene network is characterized by a scale-free distribution. This result supports the hypothesis that scale-free networks may represent the common blueprint for gene regulatory networks.

Suggested Citation

  • M. Andrecut & S. A. Kauffman & A. M. Madni, 2008. "Evidence Of Scale-Free Topology In Gene Regulatory Network Of Human Tissues," International Journal of Modern Physics C (IJMPC), World Scientific Publishing Co. Pte. Ltd., vol. 19(02), pages 283-290.
    • Handle: RePEc:wsi:ijmpcx:v:19:y:2008:i:02:n:s0129183108012091
    DOI: 10.1142/S0129183108012091
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