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Multi-Agent Simulations Of The Immune Response To Hiv During The Acute Stage Of Infection

Author

Listed:
  • R. WALSHE

    (School of Computing, Dublin City University, Dublin 9, Ireland)

  • H. J. RUSKIN

    (School of Computing, Dublin City University, Dublin 9, Ireland)

  • A. CALLAGHAN

    (School of Computing, Dublin City University, Dublin 9, Ireland)

Abstract

Results of multi-agent based simulations of the immune response to HIV during the acute phase of infection are presented here. The model successfully recreates the viral dynamics associated with the acute phase of infection, i.e., a rapid rise in viral load followed by a sharp decline to what is often referred to as a "set point", a result of T-cell response and emergence of HIV neutralizing antibodies. The results indicate that sufficient T Killer cell response is the key factor in controlling viral growth during this phase with antibody levels of critical importance only in the absence of a sufficient T Killer response.

Suggested Citation

  • R. Walshe & H. J. Ruskin & A. Callaghan, 2008. "Multi-Agent Simulations Of The Immune Response To Hiv During The Acute Stage Of Infection," International Journal of Modern Physics C (IJMPC), World Scientific Publishing Co. Pte. Ltd., vol. 19(01), pages 15-32.
    • Handle: RePEc:wsi:ijmpcx:v:19:y:2008:i:01:n:s0129183108011917
    DOI: 10.1142/S0129183108011917
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