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Biological Aging — Criteria For Modeling And A New Mechanistic Model

Author

Listed:
  • SCOTT D. PLETCHER

    (Max Planck Institute of Demographic Research, Rostock, Germany)

  • CLAUDIA NEUHAUSER

    (School of Mathematics, University of Minnesota, Minneapolis, MN, USA)

Abstract

To stimulate interaction and collaboration across scientific fields, we introduce a minimum set of biological criteria that theoretical models of aging should satisfy. We review results of several recent experiments that examined changes in age-specific mortality rates caused by genetic and environmental manipulation. The empirical data from these experiments is then used to test mathematical models of aging from several different disciplines, including molecular biology, reliability theory, physics, and evolutionary biology/population genetics. We find that none of the current models are consistent with all of the published experimental findings. To provide an example of how our criteria might be applied in practice, we develop a new conceptual model of aging that is consistent with our observations.

Suggested Citation

  • Scott D. Pletcher & Claudia Neuhauser, 2000. "Biological Aging — Criteria For Modeling And A New Mechanistic Model," International Journal of Modern Physics C (IJMPC), World Scientific Publishing Co. Pte. Ltd., vol. 11(03), pages 525-546.
    • Handle: RePEc:wsi:ijmpcx:v:11:y:2000:i:03:n:s0129183100000444
    DOI: 10.1142/S0129183100000444
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