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On the Relationship Between Carcinogenicity and Acute Toxicity

Author

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  • Bernhard Metzger
  • Edmund Crouch
  • Richard Wilson

Abstract

Parodi et al.(1) and Zeise et al.(2) found a surprising statistical correlation (or association) between acute toxicity and carcinogenic potency. In order to shed light on the questions of whether or not it is a causal correlation, and whether or not it is a statistical or tautological artifact, we have compared the correlations for the NCI/NTP data set with those for chemicals not in this set. Carcinogenic potencies were taken from the Gold et al. database. We find a weak correlation with an average value of TD50/LD50= 0.04 for the non‐NCI data set, compared with TD50/LD50= 0.15 for the NCI data set. We conclude that it is not easy to distinguish types of carcinogens on the basis of whether or not they are acutely toxic.

Suggested Citation

  • Bernhard Metzger & Edmund Crouch & Richard Wilson, 1989. "On the Relationship Between Carcinogenicity and Acute Toxicity," Risk Analysis, John Wiley & Sons, vol. 9(2), pages 169-177, June.
    • Handle: RePEc:wly:riskan:v:9:y:1989:i:2:p:169-177
    DOI: 10.1111/j.1539-6924.1989.tb01237.x
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    Cited by:

    1. Fumie Yokota & George Gray & James K. Hammitt & Kimberly M. Thompson, 2004. "Tiered Chemical Testing: A Value of Information Approach," Risk Analysis, John Wiley & Sons, vol. 24(6), pages 1625-1639, December.
    2. Pierre Crettaz & David Pennington & Lorenz Rhomberg & Kevin Brand & Olivier Jolliet, 2002. "Assessing Human Health Response in Life Cycle Assessment Using ED10s and DALYs: Part 1—Cancer Effects," Risk Analysis, John Wiley & Sons, vol. 22(5), pages 931-946, October.

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