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Carcinogenic Risk Assessment with Time‐Dependent Exposure Patterns

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  • Duncan J. Murdoch
  • Daniel Krewski

Abstract

Previous applications of carcinogenic risk assessment using mathematical models of carcinogenesis have focused largely on the case where the level of exposure remains constant over time. In many situations, however, the dose of the carcinogen varies with time. In this paper, we discuss both the classical Armitage–Doll multistage model and the Moolgavkar–Venzon–Knudson two–stage birth–death–mutation model with time‐dependent dosing regimens. Bounds on the degree of underestimation of risk that can occur through the use of a simple time‐weighted average dose are derived by means of comparison with an equivalent constant dose corresponding to the actual risk under the time‐dependent dosing regimen.

Suggested Citation

  • Duncan J. Murdoch & Daniel Krewski, 1988. "Carcinogenic Risk Assessment with Time‐Dependent Exposure Patterns," Risk Analysis, John Wiley & Sons, vol. 8(4), pages 521-530, December.
    • Handle: RePEc:wly:riskan:v:8:y:1988:i:4:p:521-530
    DOI: 10.1111/j.1539-6924.1988.tb01192.x
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    Cited by:

    1. D. Krewski & D .W. Gaylor & A. P. Soms & M. Szyszkowicz, 1993. "An Overview of the Report: Correlation Between Carcinogenic Potency and the Maximum Tolerated Dose: Implications for Risk Assessment," Risk Analysis, John Wiley & Sons, vol. 13(4), pages 383-398, August.
    2. Frédéric Dor & Roseline Bonnard & Claire Gourier‐Fréry & André Cicolella & Roland Dujardin & Denis Zmirou, 2003. "Health Risk Assessment After Decontamination of the Beaches Polluted by the Wrecked ERIKA Tanker," Risk Analysis, John Wiley & Sons, vol. 23(6), pages 1199-1208, December.

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