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Evaluation of Developmental Toxicity Data: A Discussion of Some Pertinent Factors and a Proposal

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  • William L. Hart
  • Ralph C. Reynolds
  • Walter J. Krasavage
  • Thomas S. Ely
  • R. Hays Bell
  • Robert L. Raleigh

Abstract

There is currently no well‐accepted standard method for evaluation of developmental toxicity data. This paper presents one approach to the evaluation of developmental toxicity data. We initially identify some pertinent factors that influence the interpretation of animal data and summarize the literature pertaining to these factors. Such factors include the quality and quantity of data and the relationship between maternal and developmental toxicity. We proceed with a discussion of quantitative assessment of data and propose schemes for qualitative and quantitative developmental hazard assessments.

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  • William L. Hart & Ralph C. Reynolds & Walter J. Krasavage & Thomas S. Ely & R. Hays Bell & Robert L. Raleigh, 1988. "Evaluation of Developmental Toxicity Data: A Discussion of Some Pertinent Factors and a Proposal," Risk Analysis, John Wiley & Sons, vol. 8(1), pages 59-69, March.
    • Handle: RePEc:wly:riskan:v:8:y:1988:i:1:p:59-69
    DOI: 10.1111/j.1539-6924.1988.tb01154.x
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