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Thyroid Cancer Risk from Exposure to Ionizing Radiation: A Case Study in the Comparative Potency Model

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  • Nan M. Laird

Abstract

Considerable controversy exists about the relative risk of thyroid cancer following exposure to external radiation compared to the risk after exposure to internally deposited 131I. The human epidemiological data are equivocal, and studies are not directly comparable owing to differing ages at exposure, dose ranges, and periods of follow‐up. Limited experimental data at low dose ranges support the hypothesis of equal potency in animals. This report utilizes a relative potency model to reconcile data from different sources, and to provide an estimate of thyroid cancer risk following human exposure to 131I. We utilize data from epidemiological studies of external radiation and 131I exposure in humans and data from an experimental animal study. This analysis shows that the data provide no compelling evidence to suggest that the risks accompanying external radiation or 131I exposure are different.

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  • Nan M. Laird, 1987. "Thyroid Cancer Risk from Exposure to Ionizing Radiation: A Case Study in the Comparative Potency Model," Risk Analysis, John Wiley & Sons, vol. 7(3), pages 299-309, September.
    • Handle: RePEc:wly:riskan:v:7:y:1987:i:3:p:299-309
    DOI: 10.1111/j.1539-6924.1987.tb00465.x
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    References listed on IDEAS

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    1. Roy E. Albert & Joellen Lewtas & Stephen Nesnow & Todd W. Thorslund & Elizabeth Anderson, 1983. "Comparative Potency Method for Cancer Risk Assessment: Application to Diesel Particulate Emissions," Risk Analysis, John Wiley & Sons, vol. 3(2), pages 101-117, June.
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