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Use of Acute Toxicity to Estimate Carcinogenic Risk

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  • Lauren Zeise
  • Richard Wilson
  • Edmund Crouch

Abstract

Data on the effects of human exposure to carcinogens are limited, so that estimation of the risks of carcinogens must be obtained indirectly. Current risk estimates are generally based on lifetime animal bioassays which are expensive and which take more than two years to complete. We here show how data on acute toxicity can be used to make a preliminary estimate of carcinogenic risk and give an idea of the uncertainty in that risk estimate. The estimates obtained are biased upwards, and so are useful for setting interim standards and determining whether further study is worthwhile. A general scheme which incorporates the use of such estimates is outlined, and it is shown by example how adoption of the procedures suggested could have prevented regulatory hiatus in the past.

Suggested Citation

  • Lauren Zeise & Richard Wilson & Edmund Crouch, 1984. "Use of Acute Toxicity to Estimate Carcinogenic Risk," Risk Analysis, John Wiley & Sons, vol. 4(3), pages 187-199, September.
    • Handle: RePEc:wly:riskan:v:4:y:1984:i:3:p:187-199
    DOI: 10.1111/j.1539-6924.1984.tb00138.x
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    Cited by:

    1. D. Krewski & D .W. Gaylor & A. P. Soms & M. Szyszkowicz, 1993. "An Overview of the Report: Correlation Between Carcinogenic Potency and the Maximum Tolerated Dose: Implications for Risk Assessment," Risk Analysis, John Wiley & Sons, vol. 13(4), pages 383-398, August.
    2. Gay Goodrnan & Richard Wilson, 1992. "Comparison of the Dependence of the TD50 on Maximum Tolerated Dose for Mutagens and Nonmutagens," Risk Analysis, John Wiley & Sons, vol. 12(4), pages 525-533, December.
    3. Leslie Bernstein & Lois S. Gold & Bruce N. Ames & Malcolm C. Pike & David G. Hoel, 1985. "Toxicity and Carcinogenic Potency," Risk Analysis, John Wiley & Sons, vol. 5(4), pages 263-264, December.
    4. Walter W. Piegorsch & Gregory J. Carr & Christopher J. Portier & David G. Hoel, 1992. "Concordance of Carcinogenic Response between Rodent Species: Potency Dependence and Potential Underestimation," Risk Analysis, John Wiley & Sons, vol. 12(1), pages 115-121, March.
    5. Mehdi Razzaghi & David W. Gaylor, 1996. "On the Correlation Coefficient Between the TD50 and the MTD," Risk Analysis, John Wiley & Sons, vol. 16(1), pages 107-113, February.
    6. Viay K. Gombar & Kurt Enslein & Jeffrey B. Hart & Benjamin W. Blake & Harold H. Borgstedt, 1991. "Estimation of Maximum Tolerated Dose for Long‐Term Bioassays from Acute Lethal Dose and Structure by QSAR," Risk Analysis, John Wiley & Sons, vol. 11(3), pages 509-517, September.
    7. Pierre Crettaz & David Pennington & Lorenz Rhomberg & Kevin Brand & Olivier Jolliet, 2002. "Assessing Human Health Response in Life Cycle Assessment Using ED10s and DALYs: Part 1—Cancer Effects," Risk Analysis, John Wiley & Sons, vol. 22(5), pages 931-946, October.

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