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Challenges Confronting Risk Analysis of Potential Thyroid Toxicants

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  • R. Thomas Zoeller

Abstract

Screening and testing for potential thyroid toxicants using endpoints of thyroid function, including circulating levels of thyroid hormones and thyrotropin, will not capture toxicants that directly interfere with thyroid hormone action at the receptor. The goals of the present review are to provide a critique of the literature focused on thyroid hormone and brain development as it relates to testing and evaluating thyroid toxicants, and to propose possible solutions to this perceived dilemma.

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  • R. Thomas Zoeller, 2003. "Challenges Confronting Risk Analysis of Potential Thyroid Toxicants," Risk Analysis, John Wiley & Sons, vol. 23(1), pages 143-162, February.
    • Handle: RePEc:wly:riskan:v:23:y:2003:i:1:p:143-162
    DOI: 10.1111/1539-6924.00296
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