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Absolute Risk or Relative Risk? A Study of Intraspecies and Interspecies Extrapolation of Chemical‐Induced Cancer Risk

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  • Jeanne Kuo
  • Igor Linkov
  • Lorenz Rhomberg
  • Michael Polkanov
  • George Gray
  • Richard Wilson

Abstract

We have used the CBDS database of the National Toxicology Program to study the difference between absolute risk and relative risk models for interspecies and intersex predictions of cancer risk. For no combination (class) of tumor and site is the prediction good for all chemicals. The variation in predicted risk between chemicals exceeds the difference in risks resulting from application of these two models. On the whole, it appears that relative risk is a better model.

Suggested Citation

  • Jeanne Kuo & Igor Linkov & Lorenz Rhomberg & Michael Polkanov & George Gray & Richard Wilson, 2002. "Absolute Risk or Relative Risk? A Study of Intraspecies and Interspecies Extrapolation of Chemical‐Induced Cancer Risk," Risk Analysis, John Wiley & Sons, vol. 22(1), pages 141-157, February.
    • Handle: RePEc:wly:riskan:v:22:y:2002:i:1:p:141-157
    DOI: 10.1111/0272-4332.t01-1-00012
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    References listed on IDEAS

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    1. Fredrik N. Granpth & J Carlos E. Vaca & Lars G. Ehrenberg & Margareta Â. Törnqvist, 1999. "Cancer Risk Estimation of Genotoxic Chemicals Based on Target Dose and a Multiplicative Model," Risk Analysis, John Wiley & Sons, vol. 19(2), pages 309-320, April.
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    Cited by:

    1. Mark C. Andersen & Bruce Thompson & Kenneth Boykin, 2004. "Spatial Risk Assessment Across Large Landscapes with Varied Land Use: Lessons from a Conservation Assessment of Military Lands," Risk Analysis, John Wiley & Sons, vol. 24(5), pages 1231-1242, October.

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