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Cancer Risk Estimation for Mixtures of Coal Tars and Benzo(a)pyrene

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  • D. W. Gaylor
  • S. J. Culp
  • L. S. Goldstein
  • F. A. Beland

Abstract

Two‐year chronic bioassays were conducted by using B6C3F1 female mice fed several concentrations of two different mixtures of coal tars from manufactured gas waste sites or benzo(a)pyrene (BaP). The purpose of the study was to obtain estimates of cancer potency of coal tar mixtures, by using conventional regulatory methods, for use in manufactured gas waste site remediation. A secondary purpose was to investigate the validity of using the concentration of a single potent carcinogen, in this case benzo(a)pyrene, to estimate the relative risk for a coal tar mixture. The study has shown that BaP dominates the cancer risk when its concentration is greater than 6,300 ppm in the coal tar mixture. In this case the most sensitive tissue site is the forestomach. Using low‐dose linear extrapolation, the lifetime cancer risk for humans is estimated to be: Risk

Suggested Citation

  • D. W. Gaylor & S. J. Culp & L. S. Goldstein & F. A. Beland, 2000. "Cancer Risk Estimation for Mixtures of Coal Tars and Benzo(a)pyrene," Risk Analysis, John Wiley & Sons, vol. 20(1), pages 81-86, February.
    • Handle: RePEc:wly:riskan:v:20:y:2000:i:1:p:81-86
    DOI: 10.1111/0272-4332.00008
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    Cited by:

    1. Lynne T. Haber & Alison M. Pecquet & Melissa J. Vincent & Louise M. White, 2022. "The Long Goodbye: Finally Moving on from the Relative Potency Approach to a Mixtures Approach for Polycyclic Aromatic Hydrocarbons (PAHs)," IJERPH, MDPI, vol. 19(15), pages 1-25, August.
    2. Frédéric Dor & Roseline Bonnard & Claire Gourier‐Fréry & André Cicolella & Roland Dujardin & Denis Zmirou, 2003. "Health Risk Assessment After Decontamination of the Beaches Polluted by the Wrecked ERIKA Tanker," Risk Analysis, John Wiley & Sons, vol. 23(6), pages 1199-1208, December.

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