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Carcinogenicity Studies on MTBE: Critical Review and Interpretation

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  • John H. Mennear

Abstract

Chronic inhalation of toxic concentrations of MTBE caused renal tubular cell neoplasms in male Fischer 344 rats and hepatocellular adenomas in female CD‐1 mice. In Sprague‐Dawley rats the oral administration of MTBE was associated with increased incidences of Leydig cell tumors and of lymphomas and leukemias (combined) in males and females, respectively. Neither lymphomas nor leukemias were individually increased in treated females. Leydig cell tumors are common in rats and do not predict human responses to drugs and chemicals. Neither MTBE nor its metabolite, t‐butyl alcohol, possess mutagenic potential and a second metabolite, formaldehyde, is mutagenic in vitro but in vivo results are equivocal. MTBE‐induced neoplasms are most likely produced through a nongenetic mechanism which requires chronic exposure to toxic doses. Because of the intense odor (and taste) of MTBE, humans will not tolerate either air or water concentrations sufficient to produce the cytotoxic precursors required to promote cellular proliferation.

Suggested Citation

  • John H. Mennear, 1997. "Carcinogenicity Studies on MTBE: Critical Review and Interpretation," Risk Analysis, John Wiley & Sons, vol. 17(6), pages 673-681, December.
    • Handle: RePEc:wly:riskan:v:17:y:1997:i:6:p:673-681
    DOI: 10.1111/j.1539-6924.1997.tb01274.x
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    Cited by:

    1. Sibel Osman & Olga Valerica Sapunaru & Ancaelena Eliza Sterpu & Timur Vasile Chis & Claudia I.Koncsag, 2023. "Impact of Adding Bioethanol and Dimethyl Carbonate on Gasoline Properties," Energies, MDPI, vol. 16(4), pages 1-13, February.
    2. Ayoub O. G. Abdalla & Dong Liu, 2018. "Dimethyl Carbonate as a Promising Oxygenated Fuel for Combustion: A Review," Energies, MDPI, vol. 11(6), pages 1-20, June.
    3. Wen, Lan-bin & Xin, Chen-Ying & Yang, Shyue-Cheng, 2010. "The effect of adding dimethyl carbonate (DMC) and ethanol to unleaded gasoline on exhaust emission," Applied Energy, Elsevier, vol. 87(1), pages 115-121, January.

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