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Improving the Regulation of Carcinogens by Expediting Cancer Potency Estimation

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  • Sara M. Hoover
  • Lauren Zeise
  • William S. Pease
  • Louise E. Lee
  • Mark P. Hennig
  • Laura B. Weiss
  • Carl Cranor

Abstract

The statutory language of the Safe Drinking Water and Toxic Enforcement Act of 1986 (Proposition 65; California Health and Safety Code 25249.5 et seq.) encourages rapid adoption of “no significant risk levels” (NSRLs), intakes associated with estimated cancer risks of no more than 1 in 100,000. Derivation of an NSRL for a carcinogen listed under Proposition 65 requires the development of a cancer potency value. This paper discusses the methodology for the derivation of cancer potencies using an expedited procedure, and provides potency estimates for a number of agents listed as carcinogens under Proposition 65. To derive expedited potency values, default risk assessment methods are applied to data sets selected from an extensive tabulation of animal cancer bioassays according to criteria used by regulatory agencies. A subset of these expedited values is compared to values previously developed by regulatory agencies using conventional quantitative risk assessment and found to be in good agreement. Specific regulatory activities which could be facilitated by adopting similar expedited procedures are identified.

Suggested Citation

  • Sara M. Hoover & Lauren Zeise & William S. Pease & Louise E. Lee & Mark P. Hennig & Laura B. Weiss & Carl Cranor, 1995. "Improving the Regulation of Carcinogens by Expediting Cancer Potency Estimation," Risk Analysis, John Wiley & Sons, vol. 15(2), pages 267-280, April.
    • Handle: RePEc:wly:riskan:v:15:y:1995:i:2:p:267-280
    DOI: 10.1111/j.1539-6924.1995.tb00320.x
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    References listed on IDEAS

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    1. William S. Pease, 1992. "The Role of Cancer Risk in the Regulation of Industrial Pollution," Risk Analysis, John Wiley & Sons, vol. 12(2), pages 253-265, June.
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    Cited by:

    1. Carl F. Cranor, 1995. "The Social Benefits of Expedited Risk Assessments," Risk Analysis, John Wiley & Sons, vol. 15(3), pages 353-358, June.

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