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Estimation of Acute Toxicity by Fitting a Dose‐Time‐Response Surface

Author

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  • Kai Sun
  • Gary F. Krause
  • Foster L. Mayer
  • Mark R. Ellersieck
  • Asit P. Basu

Abstract

In acute toxicity testing, organisms are continuously exposed to progressively increasing concentrations of a chemical and deaths of test organisms are recorded at several selected times. The results of the test are traditionally summarized by a dose‐response curve, and the time course of effect is usually ignored for lack of a suitable model. A model which integrates the combined effects of dose and exposure duration on response is derived from the biological mechanisms of aquatic toxicity, and a statistically efficient approach for estimating acute toxicity by fitting the proposed model is developed in this paper. The proposed procedure has been computerized as software and a typical data set is used to illustrate the theory and procedure. The new statistical technique is also tested by a data base of a variety of chemical and fish species.

Suggested Citation

  • Kai Sun & Gary F. Krause & Foster L. Mayer & Mark R. Ellersieck & Asit P. Basu, 1995. "Estimation of Acute Toxicity by Fitting a Dose‐Time‐Response Surface," Risk Analysis, John Wiley & Sons, vol. 15(2), pages 247-252, April.
    • Handle: RePEc:wly:riskan:v:15:y:1995:i:2:p:247-252
    DOI: 10.1111/j.1539-6924.1995.tb00318.x
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