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Reproducibility of the Dose‐Response Curve of Steroid‐Induced Cleft Palate in Mice

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  • Stan C. Freni
  • Mehdi Razzaghi
  • Gary E. Moore

Abstract

Pregnant CD‐1 mice were exposed to cortisone acetate at doses ranging from 20 to 100 mg/kg/ day on days 10‐13 by oral and intramuscular routes. Multiple replicate assays were conducted under identical conditions to assess the reproducibility of the dose–response curve for cleft palate. The data were fitted to the probit, logistic, multistage or Armitage‐Doll, and Weibull dose‐response model separately for each route of exposure. The curves were then tested for parallel slopes (probit and logistic models) or coincidence of model parameters (multistage and Weibull models). The 19 replicate experiments had a wide range of slope estimates, wider for the oral than for the intramuscular experiments. For all models and both routes of exposure the null hypothesis of equality of slopes was rejected at a significant level of p

Suggested Citation

  • Stan C. Freni & Mehdi Razzaghi & Gary E. Moore, 1994. "Reproducibility of the Dose‐Response Curve of Steroid‐Induced Cleft Palate in Mice," Risk Analysis, John Wiley & Sons, vol. 14(6), pages 1073-1077, December.
    • Handle: RePEc:wly:riskan:v:14:y:1994:i:6:p:1073-1077
    DOI: 10.1111/j.1539-6924.1994.tb00077.x
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