Derivation of a Target Level of Lead in Soil at Residential Sites Corresponding to a De Minimis Contribution to Blood Lead Concentration

Inability to define either a clear toxicologic threshold or a stochastic all‐or‐nothing (cancer‐type) response model for the noncarcinogenic effects of lead (Pb) in young children has posed difficulties for derivation of risk‐based target levels of Pb in residential soil. Approaches based on empirical relationships between Pb levels in blood (PbB) and Pb in soil suffer from inability to specify the numerous variables which mediate between these two quantities. Approaches based on achieving a toxicologically de minimis target PbB level (e.g., 10 μg/dl) are subject to large uncertainty in estimating the distribution of existing PbB levels in a specific exposed population and in estimating the relative contribution from nonsoil sources of Pb. The multisource contribution to the distribution of PbB makes this approach unsuited for determination of a target Pb level in a single medium. An alternative approach is presented based on achieving a de minimis contribution to PbB (ΔPbB) from soil. Contributions to Pb exposure from outdoor soil and indoor soil‐derived dust (ISDD) are modeled and appropriate values are suggested for input parameters. This analysis predicts that chronic exposure of young children to 200 μg Pb/g (ppm) in residential soil will result in a ΔPbB of 2 μg Pb/dl blood. This concentration of Pb in soil may provide an appropriate target level for residential soil when other significant sources of Pb exposure are present. In other cases, this approach can be used to predict a soil concentration of Pb corresponding to an appropriate non‐de minimisΔPbB.