IDEAS home Printed from https://ideas.repec.org/a/wly/riskan/v14y1994i5p807-813.html
   My bibliography  Save this article

Use of Biological Markers in Risk Assessment1

Author

Listed:
  • Alex McMillan
  • Alice S. Whittemore
  • Abraham Silvers
  • Yasamin DiCiccio

Abstract

Measurements of intermediate end points in the carcinogenic process may reduce uncertainty in human risk assessment from bioassay data, by identifying sources of interspecies variation and dose nonlinearity. This paper describes desirable properties of such markers: persistence, predictive power, temporal relevance, and consistency across dose rate and species. We illustrate these properties by evaluating markers for squamous cell nasal carcinoma in rodents exposed to formaldehyde. We also discuss design issues for bioassays that evaluate markers and tumors simultaneously at necropsy.

Suggested Citation

  • Alex McMillan & Alice S. Whittemore & Abraham Silvers & Yasamin DiCiccio, 1994. "Use of Biological Markers in Risk Assessment1," Risk Analysis, John Wiley & Sons, vol. 14(5), pages 807-813, October.
    • Handle: RePEc:wly:riskan:v:14:y:1994:i:5:p:807-813
    DOI: 10.1111/j.1539-6924.1994.tb00292.x
    as

    Download full text from publisher

    File URL: https://doi.org/10.1111/j.1539-6924.1994.tb00292.x
    Download Restriction: no
    File URL: https://libkey.io/10.1111/j.1539-6924.1994.tb00292.x?utm_source=ideas
    LibKey link: if access is restricted and if your library uses this service, LibKey will redirect you to where you can use your library subscription to access this item
    ---><---

    More about this item

    Statistics

    Access and download statistics

    Corrections

    All material on this site has been provided by the respective publishers and authors. You can help correct errors and omissions. When requesting a correction, please mention this item's handle: RePEc:wly:riskan:v:14:y:1994:i:5:p:807-813. See general information about how to correct material in RePEc.

    If you have authored this item and are not yet registered with RePEc, we encourage you to do it here. This allows to link your profile to this item. It also allows you to accept potential citations to this item that we are uncertain about.

    We have no bibliographic references for this item. You can help adding them by using this form .

    If you know of missing items citing this one, you can help us creating those links by adding the relevant references in the same way as above, for each refering item. If you are a registered author of this item, you may also want to check the "citations" tab in your RePEc Author Service profile, as there may be some citations waiting for confirmation.

    For technical questions regarding this item, or to correct its authors, title, abstract, bibliographic or download information, contact: Wiley Content Delivery (email available below). General contact details of provider: https://doi.org/10.1111/(ISSN)1539-6924 .

    Please note that corrections may take a couple of weeks to filter through the various RePEc services.

    IDEAS is a RePEc service. RePEc uses bibliographic data supplied by the respective publishers.