IDEAS home Printed from https://ideas.repec.org/a/wly/riskan/v14y1994i4p605-611.html
   My bibliography  Save this article

Physiologically Based Pharmacokinetic Models in Developmental Toxicology

Author

Listed:
  • E. J. O'Flaherty

Abstract

The kinetics of disposition of drugs and environmental chemicals will be altered as a result of the rapid and pronounced anatomic and physiologic changes that occur during pregnancy. These include changes in maternal intestinal motility, pulmonary tidal volume and minute volume, cardiac output, and renal function as well as in maternal tissue and fluid volumes and in the weight of the embryo/fetus and its developing organs. Physiologically‐based models of pregnancy are capable of taking these temporal changes into account. Several such models have been developed. They vary in their characteristics, depending on the chemical under consideration and the period of gestation of concern to the developers of the models. Several physiologically‐based models of gestation are outlined, and an example is given of the application of a physiologically‐based model of gestation to predict dose to the rat and mouse fetus.

Suggested Citation

  • E. J. O'Flaherty, 1994. "Physiologically Based Pharmacokinetic Models in Developmental Toxicology," Risk Analysis, John Wiley & Sons, vol. 14(4), pages 605-611, August.
    • Handle: RePEc:wly:riskan:v:14:y:1994:i:4:p:605-611
    DOI: 10.1111/j.1539-6924.1994.tb00274.x
    as

    Download full text from publisher

    File URL: https://doi.org/10.1111/j.1539-6924.1994.tb00274.x
    Download Restriction: no
    File URL: https://libkey.io/10.1111/j.1539-6924.1994.tb00274.x?utm_source=ideas
    LibKey link: if access is restricted and if your library uses this service, LibKey will redirect you to where you can use your library subscription to access this item
    ---><---

    More about this item

    Statistics

    Access and download statistics

    Corrections

    All material on this site has been provided by the respective publishers and authors. You can help correct errors and omissions. When requesting a correction, please mention this item's handle: RePEc:wly:riskan:v:14:y:1994:i:4:p:605-611. See general information about how to correct material in RePEc.

    If you have authored this item and are not yet registered with RePEc, we encourage you to do it here. This allows to link your profile to this item. It also allows you to accept potential citations to this item that we are uncertain about.

    We have no bibliographic references for this item. You can help adding them by using this form .

    If you know of missing items citing this one, you can help us creating those links by adding the relevant references in the same way as above, for each refering item. If you are a registered author of this item, you may also want to check the "citations" tab in your RePEc Author Service profile, as there may be some citations waiting for confirmation.

    For technical questions regarding this item, or to correct its authors, title, abstract, bibliographic or download information, contact: Wiley Content Delivery (email available below). General contact details of provider: https://doi.org/10.1111/(ISSN)1539-6924 .

    Please note that corrections may take a couple of weeks to filter through the various RePEc services.

    IDEAS is a RePEc service. RePEc uses bibliographic data supplied by the respective publishers.