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Human Interindividual Variability–A Major Source of Uncertainty in Assessing Risks for Noncancer Health Effects

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  • Dale Hattis
  • Ken Silver

Abstract

For noncancer effects, the degree of human interindividual variability plays a central role in determining the risk that can be expected at low exposures. This discussion reviews available data on observations of interindividual variability in (a) breathing rates, based on observations in British coal miners; (b) systemic pharmacokinetic parameters, based on studies of a number of drugs; (c) susceptibility to neurological effects from fetal exposure to methyl mercury, based on observations of the incidence of effects in relation to hair mercury levels; and (d) chronic lung function changes in relation to long‐term exposure to cigarette smoke. The quantitative ranges of predictions that follow from uncertainties in estimates of interindividual variability in susceptibility are illustrated.

Suggested Citation

  • Dale Hattis & Ken Silver, 1994. "Human Interindividual Variability–A Major Source of Uncertainty in Assessing Risks for Noncancer Health Effects," Risk Analysis, John Wiley & Sons, vol. 14(4), pages 421-431, August.
    • Handle: RePEc:wly:riskan:v:14:y:1994:i:4:p:421-431
    DOI: 10.1111/j.1539-6924.1994.tb00260.x
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    References listed on IDEAS

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    1. Dale Hattis & Linda Erdreich & Mary Ballew, 1987. "Human Variability in Susceptibility to Toxic Chemicals— A Preliminary Analysis of Pharmacokinetic Data from Normal Volunteers," Risk Analysis, John Wiley & Sons, vol. 7(4), pages 415-426, December.
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    Cited by:

    1. Junyu Zheng & H. Christopher Frey, 2005. "Quantitative Analysis of Variability and Uncertainty with Known Measurement Error: Methodology and Case Study," Risk Analysis, John Wiley & Sons, vol. 25(3), pages 663-675, June.
    2. Dale Hattis & David E. Burmaster, 1994. "Assessment of Variability and Uncertainty Distributions for Practical Risk Analyses," Risk Analysis, John Wiley & Sons, vol. 14(5), pages 713-730, October.
    3. Jeffrey C. Swartout & Paul S. Price & Michael L. Dourson & Heather L. Carlson‐Lynch & Russell E. Keenan, 1998. "A Probabilistic Framework for the Reference Dose (Probabilistic RfD)," Risk Analysis, John Wiley & Sons, vol. 18(3), pages 271-282, June.
    4. Dale Hattis & J Prerna Banati & Rob Goble & David E. Burmaster, 1999. "Human Interindividual Variability in Parameters Related to Health Risks," Risk Analysis, John Wiley & Sons, vol. 19(4), pages 711-726, August.

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    1. Dale Hattis & J Prerna Banati & Rob Goble & David E. Burmaster, 1999. "Human Interindividual Variability in Parameters Related to Health Risks," Risk Analysis, John Wiley & Sons, vol. 19(4), pages 711-726, August.
    2. Jeffrey C. Swartout & Paul S. Price & Michael L. Dourson & Heather L. Carlson‐Lynch & Russell E. Keenan, 1998. "A Probabilistic Framework for the Reference Dose (Probabilistic RfD)," Risk Analysis, John Wiley & Sons, vol. 18(3), pages 271-282, June.

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