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How Tautological Are Interspecies Correlations of Carcinogenic Potencies?

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  • David A. Freedman
  • Lois Swirsky Gold
  • Thomas H. Slone

Abstract

Crouch and Wilson demonstrated a strong correlation between carcinogenic potencies in rats and mice, supporting the extrapolation from mouse to man. Bernstein et al., however, show that the observed correlation is mainly a statistical artifact of bioassay design. Crouch et al. have a comeback. This paper will review the arguments and present some new data. The correlation is largely (but not totally) tautological, confirming results in Bernstein et al.

Suggested Citation

  • David A. Freedman & Lois Swirsky Gold & Thomas H. Slone, 1993. "How Tautological Are Interspecies Correlations of Carcinogenic Potencies?," Risk Analysis, John Wiley & Sons, vol. 13(3), pages 265-272, June.
    • Handle: RePEc:wly:riskan:v:13:y:1993:i:3:p:265-272
    DOI: 10.1111/j.1539-6924.1993.tb01078.x
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    References listed on IDEAS

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    1. Lois Swirsky Gold & Neela B. Manley & Bruce N. Ames, 1992. "Extrapolation of Carcinogenicity Between Species: Qualitative and Quantitative Factors," Risk Analysis, John Wiley & Sons, vol. 12(4), pages 579-588, December.
    2. Alexander Shlyakhter & Gay Goodman & Richard Wilson, 1992. "Monte Carlo Simulation of Rodent Carcinogenicity Bioassays," Risk Analysis, John Wiley & Sons, vol. 12(1), pages 73-82, March.
    3. Walter W. Piegorsch & Gregory J. Carr & Christopher J. Portier & David G. Hoel, 1992. "Concordance of Carcinogenic Response between Rodent Species: Potency Dependence and Potential Underestimation," Risk Analysis, John Wiley & Sons, vol. 12(1), pages 115-121, March.
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    Cited by:

    1. Kevin P. Brand & J Lorenz Rhomberg & John S. Evans, 1999. "Estimating Noncancer Uncertainty Factors: Are Ratios NOAELs Informative?," Risk Analysis, John Wiley & Sons, vol. 19(2), pages 295-308, April.
    2. Lois Swirsky Gold, 1993. "The Importance of Data on Mechanism of Carcinogenesis in Efforts to Predict Low‐Dose Human Risk," Risk Analysis, John Wiley & Sons, vol. 13(4), pages 399-401, August.

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