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Two‐Event Model for Carcinogenesis: Biological, Mathematical, and Statistical Considerations

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  • Suresh H. Moolgavkar
  • Georg Luebeck

Abstract

A two‐mutation model for carcinogenesis is reviewed. General principles in fitting the model to epidemiologic and experimental data are discussed, and some examples are given. A general solution to the model with time‐dependent parameters is developed, and its use is illustrated by application to data from an experiment in which rats exposed to radon developed lung tumors.

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  • Suresh H. Moolgavkar & Georg Luebeck, 1990. "Two‐Event Model for Carcinogenesis: Biological, Mathematical, and Statistical Considerations," Risk Analysis, John Wiley & Sons, vol. 10(2), pages 323-341, June.
    • Handle: RePEc:wly:riskan:v:10:y:1990:i:2:p:323-341
    DOI: 10.1111/j.1539-6924.1990.tb01053.x
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    Cited by:

    1. F. W. Schultz & R. Boer & H. J. de Koning, 2012. "Chapter 7: Description of MISCAN‐Lung, the Erasmus MC Lung Cancer Microsimulation Model for Evaluating Cancer Control Interventions," Risk Analysis, John Wiley & Sons, vol. 32(s1), pages 85-98, August.
    2. Teun van Dillen & Fieke Dekkers & Harmen Bijwaard & Irene Brüske & H.‐Erich Wichmann & Michaela Kreuzer & Bernd Grosche, 2016. "Modeling Lung Carcinogenesis in Radon‐Exposed Miner Cohorts: Accounting for Missing Information on Smoking," Risk Analysis, John Wiley & Sons, vol. 36(5), pages 954-967, May.
    3. Harvey J. Clewell III & Dennis W. Quinn & Melvin E. Andersen & Rory B. Conolly, 1995. "An Improved Approximation to the Exact Solution of the Two‐Stage Clonal Growth Model of Cancer," Risk Analysis, John Wiley & Sons, vol. 15(4), pages 467-473, August.
    4. Leonid G. Hanin & Andrej Yu. Yakovlev, 1996. "A Nonidentifiability Aspect of the Two‐Stage Model of Carcinogenesis," Risk Analysis, John Wiley & Sons, vol. 16(5), pages 711-715, October.
    5. William D. Hazelton & Jihyoun Jeon & Rafael Meza & Suresh H. Moolgavkar, 2012. "Chapter 8: The FHCRC Lung Cancer Model," Risk Analysis, John Wiley & Sons, vol. 32(s1), pages 99-116, August.

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