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Mediation analysis of health‐related quality of life among people living with HIV infection in China

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  • Xianhong Li
  • Ling Li
  • Honghong Wang
  • Kristopher P Fennie
  • Jia Chen
  • Ann Bartley Williams

Abstract

The effects of stigma, social support, and depressive symptoms on health‐related quality of life are well documented in the literature, but how these psychological factors interact with each other, and the combined effects when taken together on the health‐related quality of life for people living with HIV, remain unclear. This cross‐sectional study investigated 114 people living with HIV who were taking antiretroviral medication using the HIV/AIDS‐related Stigma Scale (Chinese version), the Social Support Rating Scale, the Center for Epidemiological Studies Depression Scale, and the Medical Outcomes Study–HIV health survey. Multiple linear regression analyses were used to examine the mediation effect of the psychosocial factors on health‐related quality of life. Results showed that stigma and social support did not have direct effects, but indirect effects on health‐related quality of life through a full mediation effect of depressive symptoms. The results indicate that interventions targeting depression might be the most effective approach to improving health‐related quality of life among people living with HIV who are taking antiretroviral medication in China.

Suggested Citation

  • Xianhong Li & Ling Li & Honghong Wang & Kristopher P Fennie & Jia Chen & Ann Bartley Williams, 2015. "Mediation analysis of health‐related quality of life among people living with HIV infection in China," Nursing & Health Sciences, John Wiley & Sons, vol. 17(2), pages 250-256, June.
  • Handle: RePEc:wly:nuhsci:v:17:y:2015:i:2:p:250-256
    DOI: 10.1111/nhs.12181
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    References listed on IDEAS

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    1. Honghong Wang & Jun Zhou & Ling Huang & Xianhong Li & Kristopher P Fennie & Ann B Williams, 2010. "Effects of nurse‐delivered home visits combined with telephone calls on medication adherence and quality of life in HIV‐infected heroin users in Hunan of China," Journal of Clinical Nursing, John Wiley & Sons, vol. 19(3‐4), pages 380-388, February.
    2. Nale Lehmann‐Willenbrock & Zhike Lei & Simone Kauffeld, 2012. "Appreciating age diversity and German nurse well‐being and commitment: Co‐worker trust as the mediator," Nursing & Health Sciences, John Wiley & Sons, vol. 14(2), pages 213-220, June.
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