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High‐Mobility Group Box‐1 and Endothelial Cell Angiogenic Markers in the Vitreous from Patients with Proliferative Diabetic Retinopathy

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  • Ahmed M. Abu El-Asrar
  • Mohd Imtiaz Nawaz
  • Dustan Kangave
  • Marwan Abouammoh
  • Ghulam Mohammad

Abstract

The aim of this study was to measure the levels of high‐mobility group box‐1 (HMGB1) in the vitreous fluid from patients with proliferative diabetic retinopathy (PDR) and to correlate its levels with clinical disease activity and the levels of vascular endothelial growth factor (VEGF), the angiogenic cytokine granulocyte‐colony‐stimulating factor (G‐CSF), the endothelial cell angiogenic markers soluble vascular endothelial‐cadherin (sVE‐cadherin), and soluble endoglin (sEng). Vitreous samples from 36 PDR and 21 nondiabetic patients were studied by enzyme‐linked immunosorbent assay. HMGB1, VEGF, sVE‐cadherin, and sEng levels were significantly higher in PDR patients than in nondiabetics (P = 0.008;

Suggested Citation

  • Ahmed M. Abu El-Asrar & Mohd Imtiaz Nawaz & Dustan Kangave & Marwan Abouammoh & Ghulam Mohammad, 2013. "High‐Mobility Group Box‐1 and Endothelial Cell Angiogenic Markers in the Vitreous from Patients with Proliferative Diabetic Retinopathy," Journal of Applied Mathematics, John Wiley & Sons, vol. 2013(1).
    • Handle: RePEc:wly:jnljam:v:2013:y:2013:i:1:n:697489
    DOI: 10.1155/2013/697489
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