IDEAS home Printed from https://ideas.repec.org/a/wly/apsmbi/v22y2006i5-6p631-638.html
   My bibliography  Save this article

Experimental designs for 2‐colour cDNA microarray experiments

Author

Listed:
  • Nam‐Ky Nguyen
  • E. R. Williams

Abstract

Kerr and Churchill (Biostatistics 2001; 2:183–201) showed how varieties (e.g. type of tissues, drug treatments, etc.) are paired onto arrays by a catalogue of A‐optimal incomplete block designs (IBDs) for 6–10 varieties (v), and number of blocks of size 2 between v and $ \left(v \atop 2 \right)$. These A‐optimal IBDs were obtained by (i) generating all non‐isomorphic connected graphs on v vertices using Brendan McKay's, MAKEG program (http://cs.anu.edu.au/people/bdm/nauty/) and (ii) comparing all designs of the same size on the basis of A‐optimality to obtain the best ones. In this paper we will give a quick overview on IBDs and describe an algorithmic approach to extend the mentioned catalogue. We aim at IBDs with up to 100 varieties with equal as well as unequal replications. A catalogue of 2007 IBDs is given. We will also extend the concept of even designs in Kerr and Churchill (Biostatistics 2001; 2:183–201) to row‐orthogonal designs. Copyright © 2006 John Wiley & Sons, Ltd.

Suggested Citation

  • Nam‐Ky Nguyen & E. R. Williams, 2006. "Experimental designs for 2‐colour cDNA microarray experiments," Applied Stochastic Models in Business and Industry, John Wiley & Sons, vol. 22(5‐6), pages 631-638, September.
    • Handle: RePEc:wly:apsmbi:v:22:y:2006:i:5-6:p:631-638
    DOI: 10.1002/asmb.654
    as

    Download full text from publisher

    File URL: https://doi.org/10.1002/asmb.654
    Download Restriction: no
    File URL: https://libkey.io/10.1002/asmb.654?utm_source=ideas
    LibKey link: if access is restricted and if your library uses this service, LibKey will redirect you to where you can use your library subscription to access this item
    ---><---

    More about this item

    Statistics

    Access and download statistics

    Corrections

    All material on this site has been provided by the respective publishers and authors. You can help correct errors and omissions. When requesting a correction, please mention this item's handle: RePEc:wly:apsmbi:v:22:y:2006:i:5-6:p:631-638. See general information about how to correct material in RePEc.

    If you have authored this item and are not yet registered with RePEc, we encourage you to do it here. This allows to link your profile to this item. It also allows you to accept potential citations to this item that we are uncertain about.

    We have no bibliographic references for this item. You can help adding them by using this form .

    If you know of missing items citing this one, you can help us creating those links by adding the relevant references in the same way as above, for each refering item. If you are a registered author of this item, you may also want to check the "citations" tab in your RePEc Author Service profile, as there may be some citations waiting for confirmation.

    For technical questions regarding this item, or to correct its authors, title, abstract, bibliographic or download information, contact: Wiley Content Delivery (email available below). General contact details of provider: https://doi.org/10.1002/(ISSN)1526-4025 .

    Please note that corrections may take a couple of weeks to filter through the various RePEc services.

    IDEAS is a RePEc service. RePEc uses bibliographic data supplied by the respective publishers.