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The Role of K+, Ca2+ channels, Some Endothelium Hyperpolarizing Factors in Taurine Induced Vasorelaxation in Rats Aorta

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  • Abdulsatar A. Haji

    (Dept. of Biology, Faculty of Science, University of Zakho, Zakho, Kurdistan Region, Iraq)

  • Omar A.M. Al-Habib

    (College of Science, Nawroz University, Duhok, Kurdistan Region, Iraq)

Abstract

The current study included the relaxant effect of taurine on rat’s aortic rings and the mechanism behind this relaxation. Taurine produced a potent spasmolytic effect on aortic rings at concentrations from zero to 80 mM. The results of K+ channel subtypes using specific blockers indicated that the Kv channel has a considerable role in taurine-induced relaxation, while KATP has a limited role, Exposure of aortic rings to combinations of two K+ blockers showed that KCa, Kv, and KIR play important role in taurine mediated relaxation. The endothelium-derived hyperpolarizing factors used showed responses to a variable extent in taurine mediated relaxation; since NO and cGMP played a major role whereas PGS played a minor role in taurine mediated relaxation. Finally, the results also indicated that taurine-mediated relaxation is endothelium-dependent.

Suggested Citation

  • Abdulsatar A. Haji & Omar A.M. Al-Habib, 2021. "The Role of K+, Ca2+ channels, Some Endothelium Hyperpolarizing Factors in Taurine Induced Vasorelaxation in Rats Aorta," Technium BioChemMed: Journal of Multidisciplinary Research, Biology, Chemistry and Medicine ISSN 2734 - 7990, Technium Science, vol. 2(1), pages 101-109, January.
    • Handle: RePEc:tec:bioche:v:2:y:2021:i:1:p:101-109
    DOI: 10.47577/biochemmed.v2i1.3234
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    JEL classification:

    • R00 - Urban, Rural, Regional, Real Estate, and Transportation Economics - - General - - - General
    • Z0 - Other Special Topics - - General

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