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Model based optimization of biochemical systems using multiple objectives: a comparison of several solution strategies

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  • Oscar H. Sendín
  • Julio Vera
  • Nestor V. Torres
  • Julio R. Banga

Abstract

In this work we consider multi-objective optimization problems arising from the domain of biochemical systems, namely metabolic pathways, with the ethanol production by Saccharomyces cerevisiae as a case study. The goals are to maximize the rate of production of ethanol and simultaneously minimize several internal metabolite concentrations, imposing additional constraints in order to ensure cell viability. As a result, the Pareto-optimal set is obtained for different formulations of the optimization problem. Starting from a detailed, nonlinear, kinetic model of the pathway, several recent solution strategies and other well-known techniques are compared, highlighting the advantages and drawbacks of each one.

Suggested Citation

  • Oscar H. Sendín & Julio Vera & Nestor V. Torres & Julio R. Banga, 2006. "Model based optimization of biochemical systems using multiple objectives: a comparison of several solution strategies," Mathematical and Computer Modelling of Dynamical Systems, Taylor & Francis Journals, vol. 12(5), pages 469-487, October.
    • Handle: RePEc:taf:nmcmxx:v:12:y:2006:i:5:p:469-487
    DOI: 10.1080/13873950600723442
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